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Module interactions and high temperature adaptations.

Microbial enzymes are a great resource for finding biocatalysts for future environmental friendly processes. The natural diversity developed by evolution supplies enzymes suitable in a range of different conditions, and in order to understand the factors controlling adaptation and function, this project focuses on analysis/development of a set of glycosidases/glycoside hydrolases of extremophilic origin, to perfect function under specific conditions. In addition, emphasis is put on solving the functions of individual modules and inter-modular interactions in these often modular enzymes. The goal is hence both to deepen the understanding of factors controlling enzymatic function, and to be able to supply novel/developed biocatalysts of extremophilic origin, suitable for specified applications operating under specified conditions.

Contact: Eva Nordberg Karlsson